منابع مشابه
Apolipoprotein A-V Deficiency Enhances Chylomicron
9 10 11 12 13 14 15 Linda S. Zhang 1 , Min Xu 1 , Qing Yang 1 , Robert O. Ryan 2 , Philip Howles 1 , Patrick Tso 1 16 17 18 19 20 21 22 23 1. Department of Pathology and Laboratory Medicine, University of Cincinnati College of 24 Medicine, Cincinnati, OH 45215 25 2. Children's Hospital Oakland Research Institute, Oakland, CA 94609 26 27 28 29 Running Head: ApoA-V Deficiency Enhances Chylomicron...
متن کاملNew apolipoprotein A-V: comparative genomics meets metabolism.
The availability of the human genome sequence and the recently completed draft sequences of two major mammalian model species, the mouse (Mus musculus) and the rat (Rattus norvegicus), allow researchers to apply novel approaches for gene identification and characterization, using methods of comparative and functional genomics. Recently, a new gene coding for apolipoprotein A-V was identified in...
متن کاملInherited apolipoprotein A-V deficiency in severe hypertriglyceridemia.
OBJECTIVE Mutations in LPL or APOC2 genes are recognized causes of inherited forms of severe hypertriglyceridemia. However, some hypertrigliceridemic patients do not have mutations in either of these genes. Because inactivation or hyperexpression of APOA5 gene, encoding apolipoprotein A-V (apoA-V), causes a marked increase or decrease of plasma triglycerides in mice, and because some common pol...
متن کاملThe association between small dense low density lipoprotein,apolipoprotein B, apolipoprotein B/apolipoprotein A1 ratio and coronary artery stenosis
Abstract Background: Recently, small dense low density lipoprotein (sdLDL) has been highlighted as a new risk factor for the coronary artery disease (CAD).Small dense LDLs are believed to be atherogenic since these particles are taken up more easily by arterial wall. They are readily oxidized and have reduced affinity for low density lipoprotein (LDL) receptor and increased affinity...
متن کاملIncreased prevalence of apolipoprotein E4 in type V hyperlipoproteinemia.
Type V hyperlipoproteinemia (HLP) is characterized clinically by hepatosplenomegaly, occasional eruptive xanthomas, and an increased incidence of pancreatitis. These patients have striking hypertriglyceridemia due to increased plasma chylomicron and very low density lipoprotein concentrations in the fasting state, without a deficiency of lipoprotein lipase or its activator protein, apolipoprote...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2001
ISSN: 0021-9258
DOI: 10.1074/jbc.m106888200